PRESENT DNA BASED
TECHNOLOGIES
|
|
MULTIGEN DIAGNOSTICS
|
|
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DNA/RNA based assay |
|
DNA/RNA based assay |
|
|
Target
identification by Probe
technology |
|
Target
identification by Gold Standard
nucleotide sequence
|
|
|
Probable target
identification |
|
Categorical
confirmation of
target
identification |
|
|
Lack of independent
verification |
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Independent
verification with
Genbank sequences
via Internet |
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|
Significant potential for
false positives |
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Less potential for
false positives |
|
|
Only probe based controls
for false negatives |
|
Nucleotide sequence
based controls for
false negatives |
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Low through-put
|
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High through-put |
| |
Limited Panel size (typically 3 organisms or less) |
|
Panel size includes all significant pathogens |
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Automation maximum
32 samples |
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Automation maximum
96 samples or more |
|
|
Only identification,
no genotyping |
|
Identification and
Genotyping |
